In this report, the authors present evidence-based clinical recommendations regarding the use of nonfluoride caries preventive agents. The recommendations were developed by an
expert panel convened by the American Dental Association (ADA)
Council on Scientific Affairs. The panel addressed several questions
regarding the efficacy of nonfluoride agents in reducing the incidence
of caries and arresting or reversing the progression of caries.
Types of Studies Reviewed
A panel of experts convened by
the ADA Council on Scientific Affairs, in collaboration with ADA
Division of Science staff, conducted a MEDLINE search to identify
all randomized and nonrandomized clinical studies regarding the
use of nonfluoride caries-preventive agents.
The panel reviewed evidence from 50 randomized controlled
trials and 15 nonrandomized studies to assess the efficacy of
various nonfluoride caries-preventive agents.
The panel concluded that certain nonfluoride
agents may provide some benefit as adjunctive therapies in
children and adults at higher risk of developing caries. These recommendations
are presented as a resource for dentists to consider
in the clinical decision-making process.