Thursday, July 25, 2019

Visits to the dentist decline in old age, especially among minorities


Visits to the dentist drop significantly after adults turn 80, finds a new study by researchers at NYU Rory Meyers College of Nursing and the University of Hawai'i at Mānoa.
The study, published online in the journal Research on Aging, also highlights disparities in dental visits for U.S. adults by race and country of birth, with immigrants and racial and ethnic minorities less likely to access care.
Oral health is increasingly recognized as an essential part of healthy aging. It is closely related to overall health status and quality of life, and regular dental checkups can prevent oral diseases and maintain good oral health.
However, regularly seeing a dentist is a challenge for many Americans, especially older adults, racial and ethnic minorities, and immigrant populations. Older adults face barriers such as a lack of access to quality dental care, awareness of the importance of oral health, and dental insurance coverage. Medicare does not cover most dental care, and only 12 percent of Medicare beneficiaries report having at least some dental insurance from another source to help pay dental expenses. These roadblocks to dental care increase for racial and ethnic minorities and immigrants, who may experience racial discrimination and language barriers in healthcare settings.
"To promote oral health and close racial and ethnic gaps in oral health disparities, seeing a dentist regularly is critical," said Wei Zhang, PhD, professor and chair of the Department of Sociology at the University of Hawai'i at Mānoa and the study's first author. "Failure to engage in preventive dental care may lead to serious consequences such as tooth decay, pain, tooth loss, and inflammation."
In this study, the researchers examined how often people see a dentist as they age, focusing on U.S. adults 51 years and older, and explored variations by race and country of birth. While previous studies have looked at recent trends of dental care utilization among adults in the U.S., this study extends these efforts by using longitudinal data to focus on middle-aged and older adults across an extended period of time.
The researchers used data from the Health and Retirement Study (HRS), a longitudinal study from the University of Michigan that conducts interviews with a national sample of middle-aged and older adults. They analyzed rates of dental care utilization--measured by whether someone had seen a dentist in the past two years--for 20,488 study participants of different races and ethnicities, including 17,661 U.S.-born and 2,827 foreign-born individuals.
Seventy percent of adults had visited a dentist in the past two years, but this rate decreased significantly beginning around age 80. U.S.-born adults of all races and ethnicities were more likely to see a dentist (71 percent) than immigrants (62 percent). Interestingly, the gap in care between U.S.-born adults and immigrants shrunk as people aged, suggesting that age and acculturation may play a role in decreasing oral health disparities over time.
The researchers also found that White adults had higher rates of service utilization than Black and Hispanic adults, and while the rates of service utilization decreased with age for all groups, the rates of decline for Whites were slower than others.
"Our study went beyond prior research by confirming that racial and ethnic disparities were substantial and persistent as people became older, regardless of their birthplace and while adjusting for a wide range of factors. This finding is alarming as it indicates that some unmeasured factors beyond the scope of this study, such as oral health literacy, perception of need, barriers to access, and dissatisfaction with dental care, could play important roles in explaining the disparities in dental care as people age," said Bei Wu, PhD, Dean's Professor in Global Health at NYU Rory Meyers College of Nursing and co-director of the NYU Aging Incubator, as well as the study's senior author.
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The study's findings highlight the importance of identifying racial and ethnic barriers to dental care for aging adults and developing culturally competent programs to meet the dental needs of the increasingly diverse U.S. population.

Friday, July 19, 2019

Big Sugar and neglect by global health community fuel oral health crisis


Oral diseases present a major global public health burden, affecting 3.5 billion people worldwide, yet oral health has been largely ignored by the global health community, according to a new Lancet Series on Oral Health.

The Lancet
  • Oral diseases present a major global public health burden, affecting 3.5 billion people worldwide, yet oral health has been largely ignored by the global health community, according to a new Lancet Series on Oral Health.
  • With a treat-over-prevent model, modern dentistry has failed to combat the global challenge of oral diseases, giving rise to calls for the radical reform of dental care
  • The burden of oral diseases is on course to rise as more people are exposed to the underlying risk factors of oral diseases, including sugar, tobacco and alcohol
  • Emerging evidence of the food, beverage, and sugar industry's influence on dental research and professional bodies raises fresh concern
Oral health has been isolated from traditional healthcare and health policy for too long, despite the major global public health burden of oral diseases, according to a Lancet Series on Oral Health, published today in The Lancet. Failure of the global health community to prioritise the global burden of oral health has led to calls from Lancet Series authors for the radical reform of dental care, tightened regulation of the sugar industry, and greater transparency around conflict of interests in dental research.
Oral diseases, including tooth decay, gum disease and oral cancers, affect almost half of the global population, with untreated dental decay the most common health condition worldwide. Lip and oral cavity cancers are among the top 15 most common cancers in the world. In addition to lower quality of life, oral diseases have a major economic impact on both individuals and the wider health care system.
Accessing dental care continues to present the highest cost barrier compared to any other healthcare service in the United States (U.S.) and the highest dental expenditures globally were found for the U.S. ($129.1 billion). [1]
The Lancet Series on Oral Health led by University College London (UCL) researchers brought together 13 academic and clinical experts from 10 countries, including the US, to better understand why oral diseases have persisted globally over the last three decades, despite scientific advancements in the field, and why prevalence has increased in low- and middle- income countries (LMIC), and among socially disadvantaged and vulnerable people, no matter where they live. [2]
A tipping point for global oral health "Dentistry is in a state of crisis," said Professor Richard Watt, Chair and Honorary Consultant in Dental Public Health at UCL and lead author of the Series. "Current dental care and public health responses have been largely inadequate, inequitable, and costly, leaving billions of people without access to even basic oral health care. While this breakdown in the delivery of oral healthcare is not the fault of individual dental clinicians committed to caring for their patients, a fundamentally different approach is required to effectively tackle to the global burden of oral diseases." [3]
In high-income countries (HIC), dentistry is increasingly technology-focused and trapped in a treatment-over-prevention cycle, failing to tackle the underlying causes of oral diseases. Oral health conditions share many of the same underlying risk factors as non-communicable diseases, such as sugar consumption, tobacco use and harmful alcohol consumption.
Professor Robert J. Weyant, DMD, DrPH Professor and Chair, University of Pittsburgh, Department of Dental Public Health, said: "The U.S. continues to struggle with how to best ensure access to affordable dental care for many individuals. This has led to ongoing suffering for many with oral disease and significant disparities in oral health for vulnerable populations such as poor families, ethnic minorities, and the elderly. The Affordable Care Act helped to expand access to dental care for millions but many still remain unable receive needed care, highlighting an urgent need for improvements in dental health policy." [4]
In middle-income countries the burden of oral diseases is considerable, but oral care systems are often underdeveloped and unaffordable to the majority. In low-income countries the current situation is most bleak, with even basic dental care unavailable and most disease remaining untreated.
Coverage for oral health care in LMIC is vastly lower than in HIC with median estimations ranging from 35% in low-, 60% in lower-middle, 75% in upper middle, and 82% in high income countries.
Sugar, alcohol and tobacco industries fuel global burden The burden of oral diseases is on course to rise, as more people are exposed to the main risk factors of oral diseases. Sugar consumption, the underlying cause of tooth decay, is rising rapidly across many LMIC. While sugary drinks consumption is highest in HIC, the growth in sales of sugary drinks in many LMIC is substantial. By 2020, Coca-Cola intend to spend US$12 billion on marketing their products across Africa [5] in contrast to WHO's total annual budget of $4.4 billion (2017).
"The use of clinical preventive interventions such as topical fluorides to control tooth decay is proven to be highly effective, yet because it is seen as a 'panacea', it can lead to many losing sight of the fact that sugar consumption remains the primary cause of disease development." said Watt. "We need tighter regulation and legislation to restrict marketing and influence of the sugar, tobacco and alcohol industries, if we are to tackle the root causes of oral conditions."
Writing in a linked commentary, Cristin E Kearns of the University of California and Lisa A Bero of the University of Sydney raise additional concerns with the financial links between dental research organisations and the industries responsible for many of these risk factors.
"Emerging evidence of industry influence on research agendas contributes to the plausibility that major food and beverage brands could view financial relationships with dental research organisations as an opportunity to ensure a focus on commercial applications for dental caries interventions--eg, xylitol, oral hygiene instruction, fluoridated toothpaste, and sugar-free chewing gum--while deflecting attention from harm caused by their sugary products."
Lancet Series authors argue a pressing need exists to develop clearer and more transparent conflict of interest policies and procedures, and to restrict and clarify the influence of the sugar industry on dental research and oral health policy.
Radical reform of dentistry needed Lancet Series authors have called for wholesale reform of the dental care model in five key areas:
    1. Close the divide between dental and general healthcare 2. Educate and train the future dental workforce with an emphasis on prevention
    3. Tackle oral health inequalities through a focus on inclusivity and accessibility
    4. Take a stronger policy approach to address the underlying causes of oral diseases
    5. Redefine the oral health research agenda to address gaps in LMIC knowledge
Dr Jocalyn Clark, an Executive Editor at The Lancet, said: "Dentistry is rarely thought of as a mainstream part of healthcare practice and policy, despite the centrality of the mouth and oral cavity to people's well-being and identity. A clear need exists for broader accessibility and integration of dental services into healthcare systems, especially primary care, and for oral health to have more prominence within universal health coverage commitments. Everyone who cares about global health should advocate to end the neglect of oral health."
APPENDIX OF KEY FACTS & STATISTICS Oral disease: types and causes
  • The key oral health conditions include: dental caries (tooth decay) [localised destruction of dental hard tissues (enamel and dentine) by acidic by-products from the bacterial fermentation of free sugars]; periodontal (gum) disease [chronic inflammatory conditions that affect the tissues surrounding and supporting the teeth]; and oral cancer [squamous cell carcinoma is the most common type of oral cancer].
  • The main cause of periodontal disease is poor oral hygiene leading to an accumulation of pathogenic microbial biofilm (plaque) at and below the gingival margin. Tobacco use is also an important independent risk factor for periodontal disease.
  • The major risk factors for oral cancers are tobacco use, alcohol consumption, and areca nut (betel quid) chewing. In many high-income countries (HIC), human papilloma virus (HPV) infection is responsible for a steep rise in the incidence of oropharyngeal cancers among young people.
  • Oral diseases can lower quality of life in many ways, including pain, infections, problems with eating and speaking, diminished confidence, and disruption to social, work, and school activities.
The global burden of oral disease
  • The most recent data from 2015 confirm that untreated caries in the permanent dentition remain the most common health condition globally (34·1%).
  • A 4% decrease in the number of prevalent cases of untreated dental caries occurred globally from 1990 (31,407 cases per 100 000) to 2017 (30,129 cases per 100 000).
  • The global burden of untreated dental caries for primary and permanent dentition has remained relatively unchanged over the past 30 years.
  • Epidemiological evidence indicates that lifetime prevalence of dental caries has decreased in the past four decades, but this is mainly in HIC, with the most substantial decrease seen in 12-year-old children.
  • Data from 2018 show that oral cancer has the highest incidence among all cancers in Melanesia and south Asia among males, and is the leading cause of cancer-related mortality among males in India and Sri Lanka.
Inequalities in oral disease
  • Case-control studies showed a consistent association between low socioeconomic status and oral cancer in both LMIC and HIC, even after adjustment for behavioural confounders.
  • Extreme oral health inequalities exist for the most marginalised and socially excluded groups in societies, such as homeless people, prisoners, those with long term disabilities, refugees, and indigenous groups, which serves as a classic example of a so-called cliff edge of inequality
  • Indigenous children, even in HIC (Australia, Canada, New Zealand, and USA), are particularly vulnerable, with the prevalence of early childhood caries ranging from 68% to 90%.
Prevention
  • WHO recommends that free sugars intake should be restricted to less than 10% of total energy highlighting that for further benefits, restriction in sugar consumption should be now more than 5% of total energy; however, many countries do not meet these guidelines.
  • While topical fluorides are proven clinical preventive agents, caries will still develop in the presence of free sugars above 10% of total energy intake. Even where exposure to fluoride is optimal, evidence suggests that free sugars exposure as low as of total energy may still carry a risk of caries.

Commentary: Sugar industry ties to professional dental organizations must be addressed


Oral diseases, such as tooth decay, gum disease and oral cancers, are a major health burden affecting 3.5 billion people worldwide, but are largely ignored by the global health community, according to a series on oral health in Oral diseases, such as tooth decay, gum disease and oral cancers, are a major health burden affecting 3.5 billion people worldwide, but are largely ignored by the global health community, according to a series on oral health in The Lancet that publishes July 20, 2019.
In a commentary accompanying the series, Cristin Kearns, DDS, MBA, of UCSF, and Lisa Bero, PhD, of the University of Sydney, express growing concern that the dental profession will not make meaningful progress in combatting the oral health epidemic until it addresses the sugar industry's influence on dental research and professional bodies.
"Dental research organizations have only recently woken up to the fact that their research activities haven't focused on sugars for many years, and very few people realize that these organizations have financial relationships with global candy, ice cream, sugary beverage and snack companies," said Kearns, an assistant professor in the UCSF School of Dentistry and Philip R. Lee Institute for Health Policy Studies. "While these relationships may be slightly less shocking when one considers these companies also sell oral health products, we can't lose sight of the fact that in many cases, these are the same companies that are opposing sugar reduction policies, such as sugary beverage taxes."
The commentary lists the corporate members of the European Organisation for Caries Research (ORCA), which include Cloetta, a Nordic confectionary company; Unilever, a global consumer goods company selling ice cream and sugary beverages; and Mars Wrigley Confectionary, a leader in production of chewing gum, chocolate mints and fruity confections. International Association for Dental Research (IADR) corporate members include Unilever and Mondel?z International, one of the world's largest snack companies.
The authors note that industry funding presents a conflict of interest (COI) and a risk of bias in how research is designed, conducted and published. It can drive research agendas away from studying product harms or towards topics that may distract from these harms, such as dental caries interventions with commercial applications (e.g., xylitol, oral hygiene instruction, fluoridated toothpaste and sugar-free chewing gum), rather than prevention.
"Dental research organizations have made inconsistent progress towards the disclosure and management of COI," wrote Kearns and Bero, who also is a prominent researcher in the field of pharmaceutical COI. "The extent of undisclosed financial ties with the sugary food and beverage industry is uncertain because existing transparency databases focus mainly on pharmaceutical industry payments. Furthermore, disclosure alone does not manage COI."
The authors advise adding dentistry to the key recommendations spelled out in a 2009 report by the U.S. Institute of Medicine (now National Academy of Medicine) on conflicts of interest in medical research, education, and practice for pharmaceutical, medical device and biotechnology companies.
To specifically manage financial conflicts within the sugary food and beverage industry, Kearns and Bero recommend dental research organizations take the following actions:

    Adopt COI policies consistent with the 2009 Institute of Medicine Report for the organization and any related entities (e.g., dental journals). Publicly report industry payments to dentists, researchers, health care institutions, professional societies and continuing dental education providers.
    Bar researchers with a COI from doing research with human participants, except when the investigators' expertise is essential to the safe and rigorous conduct of the research.
    Prohibit or end relationships with industry that present unacceptable risks of undue influence over professional decision-making or a loss of public trust.
    Reduce industry influence in the development of clinical practice guidelines by requiring the majority of guideline committee members and committee chair be free of financial COI.
    Establish policies at the board level to identify, limit and manage institution-level COI.
    Develop incentives to promote the institutional adoption and implementation of policies recommended by the Institute of Medicine report for medical research, education and practice.
The Lancet Oral Health Series includes two papers and two commentaries from 13 academic researchers from 10 countries. The series provides an analysis of the health and economic burdens of dental decay, which disproportionately affect low- and middle-income countries, and issues a call for action on oral health within the global agendas for non-communicable diseases and universal health coverage.
The two Lancet studies, on which Kearns is also a co-author, advocate for widespread dental reform. The researchers encourage closing the divide between dental and general health care; educating and training the future dental workforce to focus on prevention; tackling oral health inequalities through inclusivity and accessibility; strengthening policy to address the underlying causes of oral diseases; and redefining the oral health research agenda to address knowledge gaps in lower- and middle-income countries.
Untreated dental decay is the most common health condition worldwide, and lip and oral cavity cancers are among the top 15 most common cancers. Sugar consumption, the underlying cause of tooth decay and a common risk factor for obesity and associated diseases, is rising rapidly across many low- and middle-income countries. The papers emphasize that prevention of tooth decay requires global implementation of the World Health Organization's guideline recommending individuals consume less than 10 percent of total energy from free sugars, preferably below 5 percent.

Friday, July 12, 2019

Root canal work not so bad after all


Root canal work is not as bad as people think when compared to other dental procedures. Self-reporting of their dental health suggests that patients find the procedure no worse than other dental work which overturns the popular belief that root canal work is the most unpleasant dental treatment.
Dr Tallan Chew, postgraduate student, Adelaide Dental School, University of Adelaide co-authored the study.
"Information about 1096 randomly selected Australian people aged 30-61 was collected through questionnaires, dental records and treatment receipts in 2009. Their self-rated dental health score was checked when they had their dental work and two years later," she says.
"Patients who had root canal work reported similar oral health-related quality of life as people who had other types of dental work.
"The effect of root canal work on patients' oral health-related quality of life was compared to other kinds of dental work such as tooth extraction, restoration of teeth, repairs to the teeth or gum treatment, preventative treatment and cleaning."
Every year millions of root canal treatments are performed globally (more than 22 million in the USA alone), which may have a profound positive effect on the quality of life of patients. A root canal treatment repairs and saves a tooth that is badly decayed or is infected. During a root canal procedure, the nerve and pulp are removed and the inside of the tooth is cleaned and sealed. Most people associate having root canal work with a lot of pain and discomfort.
"There is growing interest in the dental profession to better understand the effect and impact oral diseases and their associated treatment, such as root canal work, have on patients' quality of life," says Professor Giampiero Rossi-Fedele, Head of Endodontics at Adelaide Dental School, University of Adelaide who co-authored the study.
"A biopsychosocial view of health is increasingly replacing a purely biomedical model.
"Treatment outcomes need to be re-examined from a patient-based perspective using self-reported measures as this more accurately reflects the patients' perception of treatment outcomes and the effect it has on their overall well-being.
"Patient-reported treatment outcomes are now the principle driving force behind treatment needs, as opposed to clinician-based treatment outcomes.
"With this change in emphasis, the perspectives of patients and their relatives are important factors in identifying need for treatment, treatment planning, and determining outcomes from any health care intervention as part of shared decision making," says Professor Rossi-Fedele.

Tuesday, July 9, 2019

New antibacterial fillings may combat recurring tooth decay



Tooth decay is among the costliest and most widespread bacterial diseases. Virulent bacteria cause the acidification of tooth enamel and dentin, which, in turn, causes secondary tooth decay.
A new study by Tel Aviv University researchers finds potent antibacterial capabilities in novel dental restoratives, or filling materials. According to the research, the resin-based composites, with the addition of antibacterial nano-assemblies, can hinder bacterial growth and viability on dental restorations, the main cause of recurrent cavities, which can eventually lead to root canal treatment and tooth extractions.
Research for the study was led by Dr. Lihi Adler-Abramovich and TAU doctoral student Lee Schnaider in collaboration with Prof. Ehud Gazit, Prof. Rafi Pilo, Prof. Tamar Brosh, Dr. Rachel Sarig and colleagues from TAU's Maurice and Gabriela Goldschleger School of Dental Medicine and George S. Wise Faculty of Life Sciences. It was published in ACS Applied Materials & Interfaces on May 28.
"Antibiotic resistance is now one of the most pressing healthcare problems facing society, and the development of novel antimicrobial therapeutics and biomedical materials represents an urgent unmet need," says Dr. Adler-Abramovich. "When bacteria accumulate on the tooth surface, they ultimately dissolve the hard tissues of the teeth. Recurrent cavities -- also known as secondary tooth decay -- at the margins of dental restorations results from acid production by cavity-causing bacteria that reside in the restoration-tooth interface."
This disease is a major causative factor for dental restorative material failure and affects an estimated 100 million patients a year, at an estimated cost of over $30 billion.
Historically, amalgam fillings composed of metal alloys were used for dental restorations and had some antibacterial effect. But due to the alloys' bold color, the potential toxicity of mercury and the lack of adhesion to the tooth, new restorative materials based on composite resins became the preferable choice of treatment. Unfortunately, the lack of an antimicrobial property remained a major drawback to their use.
"We've developed an enhanced material that is not only aesthetically pleasing and mechanically rigid but is also intrinsically antibacterial due to the incorporation of antibacterial nano-assemblies," Schnaider says. "Resin composite fillings that display bacterial inhibitory activity have the potential to substantially hinder the development of this widespread oral disease."
The scientists are the first to discover the potent antibacterial activity of the self-assembling building block Fmoc-pentafluoro-L-phenylalanine, which comprises both functional and structural subparts. Once the researchers established the antibacterial capabilities of this building block, they developed methods for incorporating the nano-assemblies within dental composite restoratives. Finally, they evaluated the antibacterial capabilities of composite restoratives incorporated with nanostructures as well as their biocompatibility, mechanical strength and optical properties.
"This work is a good example of the ways in which biophysical nanoscale characteristics affect the development of an enhanced biomedical material on a much larger scale," Schnaider says.
"The minimal nature of the antibacterial building block, along with its high purity, low cost, ease of embedment within resin-based materials and biocompatibility, allows for the easy scale-up of this approach toward the development of clinically available enhanced antibacterial resin composite restoratives," Dr. Adler-Abramovich says.
The researchers are now evaluating the antibacterial capabilities of additional minimal self-assembling building blocks and developing methods for their incorporation into various biomedical materials, such as wound dressings and tissue scaffolds.

Thursday, July 4, 2019

Are you sure it's burning mouth syndrome?



Not all burning mouths are the result of a medical condition known as "burning mouth syndrome" (BMS) and physicians and researchers need better standards for an appropriate diagnosis, according to new research at the School of Dental Medicine at Case Western Reserve University.
BMS is a painful, complex condition associated with a chronic or recurring burning, scalding or tingling feeling in the mouth--sometimes accompanied by a metallic taste or dry mouth sensation.
But because other conditions have similar symptoms, diagnosing BMS can be difficult, said Milda Chmieliauskaite, a researcher and assistant professor of oral and maxillofacial medicine at the dental school.
"The issues with misdiagnosis, depend to some extent on the context, but include resources, money and patient discomfort," she said. So if a patient is misdiagnosed with burning mouth syndrome, but actually suffers from burning due to dry mouth, the patient will receive treatment for the wrong condition and the symptoms of burning will not improve.
"Often, these patients see several providers--taking up a lot of health-care resources--before they find out what's going."
That's because many dentists and clinicians aren't trained well on the topic, she said. The current method for making a diagnosis is ruling out other disorders.
So treating BMS should be approached with caution, said Chmieliauskaite, who co-authored research recently published by Oral Diseases as part of the World Workshop on Oral Medicine VII.
"A lot of the other things that cause burning in the mouth (such as diabetes, anemia and dry mouth) can be easily treated," Chmieliauskaite said.
The specific cause of BMS is uncertain, she said, but some evidence shows that it may be related to nerve dysfunction. Sometimes, chewing gum or eating certain foods lessens pain symptoms.
Best estimates are that between .1% and 4% of the population is affected by BMS, Chmieliauskaite said. The condition affects females more.
In a review of clinical trials internationally between 1994 and 2017, Chmieliauskaite and an international research team found that many of the participants may have had an underlying condition that could have explained their BMS symptoms.
Chmieliauskaite said BMS clinical trials need more rigorous standards. "We need a consensus for a single definition of BMS that includes specific inclusion and exclusion criteria," she said. "This will help us in moving the field forward in understanding of the actual disease."
"And there's still a lot more we need to study," she said.