Monday, August 30, 2021

Research finds ‘very low rates’ of dental fluoride varnish treatment for young children

 Affordable Care Act mandates insurance coverage for the service during well-child visits to medical provider

 Fewer than 5% of well-child visits for privately insured young children included a recommended dental fluoride varnish application, despite mandatory insurance coverage for this service, according to a University of Massachusetts Amherst study.

Fluoride varnish helps reduce tooth decay, which affects nearly 25% of 2- to 5-year-olds and more than half of 6- to 8-year-olds in the U.S., according to earlier studies. 

The new research, published Aug. 30 in JAMA Network Open, was the first to assess delivery of this evidence-based service recommended by the U.S. Preventive Task Force and the American Academy of Pediatrics for privately insured children. Previous research showed that fewer than 8% of 1- to 5-year-olds covered by Medicaid receive fluoride varnish in medical settings. 

While Medicaid in most states has paid for fluoride varnish applications for at least a decade, private insurance coverage was mandated in 2015 under the Affordable Care Act with no cost-share for families, explains lead author Kimberley Geissler, associate professor of health policy and management in the UMass Amherst School of Public Health and Health Sciences.

“Most kids are not getting fluoride varnish applications in the medical office,” Geissler says. “I wasn’t surprised due to the low rates we’ve seen in Medicaid-covered children, but I was disappointed that it wasn’t higher. Medical providers are not required to do this; it’s like a mammogram. It’s recommended and it’s good and they should do it, and the questions we were looking at were: do they do it and how often?”

Co-author and pediatrician Dr. Sarah Goff, associate professor of health policy and management at UMass Amherst, saysknowing that very low rates of fluoride varnish application are found in both Medicaid and commercially insured populations is important because it suggests that broader, system-level barriers exist. “As a health services researcher and primary care pediatrician, I am excited about our next steps of learning what sorts of things are presenting barriers to applying fluoride varnish and developing strategies for overcoming these barriers so all eligible children receive this important preventive intervention,” Goff says.

The JAMA study is part of a larger project in Massachusetts that will delve into more complex questions, such as whymedical providers aren’t applying fluoride varnish during well-child visits. The preventive treatment is especially critical in light of the statistic that fewer than one in three children under age 5 have an annual dentist visit, where this service also could be provided.

The research team, including senior author Ashley Kranz of the RAND Corporation, examined data from 2016-2018 for privately insured young children in Connecticut, Maine, New Hampshire and Rhode Island.

The sample included 328,661 well-child visits in the four states. Fluoride varnish application was more common among visits for younger children. A 2-year-old was nearly 8 percentage points more likely to receive fluoride varnish than a 5-year-old, an analysis of the data showed.

Fluoride varnish applications were most common in Rhode Island, with a regression-adjusted probability of 8.7%. New Hampshire had the lowest rate, with a regression-adjusted probability of 2.2%.

Geissler points to one “hopeful takeaway” from the study: the regression-adjusted probability of fluoride varnish application increased from 3.6% in 2016 to 5.8% in 2018. “That’s still really low,” she says, “but it did go up over time.”

The study concludes, “Although increases over time were encouraging, very low rates of fluoride varnish in medical settings suggest substantial expansion of this service in medical settings is critical for improving children’s oral health and overall well-being.” 


Wednesday, August 25, 2021

Gum disease linked with new onset heart disease

 

Reports and Proceedings

EUROPEAN SOCIETY OF CARDIOLOGY

Sophia Antipolis, France – 25 Aug 2021:  Gum disease is associated with an increased risk of cardiovascular disease: the more severe the periodontitis, the higher the risk. The findings are presented at ESC Congress 2021.1 The association was particularly evident among patients who had experienced a heart attack in the past.

Study author Dr. Giulia Ferrannini of the Karolinska Institute, Stockholm, Sweden said: “Our study suggests that dental screening programmes including regular check-ups and education on proper dental hygiene may help to prevent first and subsequent heart events.”

The Swedish PAROKRANK study previously showed that periodontitis (gum disease) was significantly more common in first time heart attack patients compared to their healthy peers of the same age and sex and living in the same area.2

This long-term follow-up of PAROKRANK participants investigated whether the presence of gum disease, both in heart attack patients and their healthy peers, was related to an increased risk of new cardiovascular events over time.

The analysis included 1,587 participants with an average age of 62 years. Participants underwent a dental examination between 2010 and 2014: 985 were classified as healthy, 489 had moderate periodontitis, and 113 had severe periodontitis. Participants were followed up for the occurrence of cardiovascular events and death. The primary endpoint was a composite of all-cause death, non-fatal heart attack or stroke, or severe heart failure. Follow-up data were collected until the end of 2018 from Swedish national death and patient registries.

During an average follow up of 6.2 years, there were 205 primary endpoint events. In the overall cohort, participants with periodontitis at baseline had 49% higher odds of the primary endpoint compared to those with healthy gums. The probability of the primary endpoint rose with increasing severity of gum disease.

When heart attack patients and healthy controls were assessed separately, the graded relationship between gum disease severity and the primary endpoint was significant only for patients.

Dr. Ferrannini said: “The risk of experiencing a cardiovascular event during follow-up was higher in participants with periodontitis, increasing in parallel with the severity. This was particularly apparent in patients who had already experienced a myocardial infarction.”

She added: “We postulate that the damage of periodontal tissues in people with gum disease may facilitate the transfer of germs into the bloodstream. This could accelerate harmful changes to the blood vessels and/or enhance systemic inflammation that is harmful to the vessels.”

Dr. Ferrannini concluded: “It is important to underline that the quality of care in Sweden is high, as confirmed by the overall low number of total events during follow-up. Despite this, gum disease was linked with an elevated likelihood of cardiovascular disease or death.”


Tuesday, August 3, 2021

Dental mitigation strategies to reduce aerosolization of SARS-CoV-2


Peer-Reviewed Publication

INTERNATIONAL & AMERICAN ASSOCIATIONS FOR DENTAL RESEARCH

Alexandria, Va., USA — Limiting infection transmission is central to the safety of all in dentistry, particularly during the current SARS-CoV-2 pandemic, yet many dental procedures unavoidably generate aerosols. In the study “Dental Mitigation Strategies to Reduce Aerosolization of SARS-CoV-2,” published in the Journal of Dental Research (JDR), researchers at the University of Leeds, England, UK used a ‘phantom head’ model to mimic dental procedures in a multifaceted approach to measure aerosol dispersal in a dental surgery setting and determine the potential of different mitigation strategies to reduce the infection risk to the dental team from bioaerosol exposure during routine dental procedures.

In a dental surgery setting, crown preparation and root canal access procedures were performed with an air turbine or high-speed contra-angle hand-piece (HSCAH) operated with water cooling, with mitigation via rubber dam or high-volume aspiration and a no mitigation control. A phantom head was used with a flow of artificial saliva infected with Φ6-bacteriophage, a surrogate virus for SARS-CoV-2. Bioaerosol dispersal was measured using agar settle plates lawned with the Φ6-bacteriophage host, Pseudomonas syringae. Viral air concentrations were assessed by active air sampling, and particle size and quantities were monitored using optical particle counters.

Bioaerosol levels were clearly diminished when using the HSCAH compared with the air turbine. Use of rubber dam or high volume evacuation were also effective in reducing bioaerosols and splatter.

While this model represents a worst-case scenario for possible SARS-CoV-2 dispersal, these data showed that the use of HSCAHs or other mitigation strategies can vastly reduce the risk of viral aerosolization, and suggests a prolonged clinic fallow time is not necessary.

“It is imperative to understand the inherent risks of viral dispersion associated with dental procedures and the efficacy of available mitigation strategies,” said JDR Editor-in-Chief Nicholas Jakubovics, Newcastle University, England. “To our knowledge, this study is the first to report the aerosolization in a simulated dental setting of bacteriophage, as a surrogate for SARS CoV2, as a marker for risk determination. The data described here present a clear picture of how risk of SARS-CoV-2 and similar biological hazards can be greatly attenuated using mitigation strategies including HSCAHs.”

Reducing COVID-19 risk during dentist appointments

Dentists could significantly increase the number of patients they see during the pandemic by switching the drills they use, according to new research. 

The study investigated whether different drill types increased or reduced the spread of aerosol spray in a dental surgery. Reducing aerosol spray results in a safer environment for patients and the dental team. 

The findings show that the time taken to prepare safe surgeries between appointments could be radically reduced by changing drills, potentially resulting in millions more treatments being carried out. 

The study, led by the University of Leeds, compared the aerosol patterns produced by dental drills rotated by air streams - that are most commonly used by UK dentists - to those produced by electric powered drills. 

Instead of simply mapping the spread of water spray during treatment, the research team instead introduced a virus that is similar in size and structure to the SARS-CoV-2 virus that causes COVID-19. 

Their results show that by replacing the high-speed air drills with lower speed electric drills, aerosol spray was virtually eliminated, creating a safer environment for both patients and the dental team. 

The research, funded by the British Endodontic Society, is published in the Journal of Dental Research. 

Lead clinical author Professor Brian Nattress, from Leeds’ School of Dentistry, said: “The issue for dentists during the coronavirus pandemic is that their routine work involves creating an aerosol spray in a confined space with an associated risk of airborne spread of COVID-19. 

“This is the first time the spread of a harmless COVID-19-like virus has been analysed during routine drilling procedures. 

“If the spread of that aerosol spray can be reduced or eradicated, that has enormous, positive implications for how dentists can go about their daily business not just during the coronavirus pandemic, but also during future virus outbreaks.” 

During the first national lockdown in England between March and June 2020, all dental surgeries were closed. 

Since reopening, because patients may be asymptomatic carriers of the SARS-CoV-2 virus when attending a dentist appointment, strict regulations have been introduced to ensure work areas are safe and prepared appropriately between appointments. Additional protective measures have been required for the dental team delivering patient care. This has led to much longer gaps between treating patients.  

Before the pandemic, about 18 million adults and children attended an NHS dental appointment each year in England. 

Reports by charity HealthWatch point to a growing backlog of patients waiting to see a dentist, with fears this could rise as the SARS-CoV-2 virus is expected to remain prevalent in the general population for many months more. 

Adjustments to the pandemic measures require high quality evidence to show how dentists can reduce the risk of spreading the SARS-CoV-2 virus when carrying out aerosol generating procedures (AGPs) during dental treatments. 

During the new research tests, use of the electric drill rather than an air drill led to a 99.98% reduction in aerosol spread of the virus into the air. 

When a dental suction tool was added, there was no detectable virus on surfaces or in air samples taken six to 10 minutes afterwards. 

The new research was carried out by the School of Dentistry, School of Civil Engineering and the Leeds Dental Institute. 

The research team set up simulated dental treatments in a real surgery scenario and - for the first time ever - used a harmless virus to track the spread of aerosols in the air and on surfaces. 

A dummy head and simulated saliva were used to measure the difference between the level of aerosols generated using a conventional air-driven dentist’s drill and a more modern electric hand piece. 

Professor David Wood, Director of Research and Innovation in the School of Dentistry, is co-author of the report. 

He said: “This robust scientific evidence addresses how the risks associated with the spread of the SARS-CoV-2 virus via dental drills can be successfully managed. 

“The recommendation we make in the report will help more people access the dental care they need, but haven’t been able to get since early 2020.” 

In light of the many restraints placed on dentists globally since the beginning of the pandemic, the research team is calling for further and essential studies to find different strategies to control the spread of dental aerosols and help to reduce the backlog of patients. 

Further information 

“Dental mitigation strategies to reduce aerosolization 1 of SARS-CoV-2”, is published on 2 August 2021 in the Journal of Dental Research. 

DOI: https://doi.org/10.1177/00220345211032885 

Wednesday, July 21, 2021

Preventing approximal caries in primary teeth with topical fluorides


INTERNATIONAL & AMERICAN ASSOCIATIONS FOR DENTAL RESEARCH

Research News

Alexandria, Va., USA - Parach Sirivichayakul, Mahidol University, Bangkok, Thailand, presented the poster "Preventing Approximal Caries in Primary Teeth With Topical Fluorides" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021.

There is limited evidence regarding the use of silver diamine fluoride (SDF) for caries prevention in primary teeth. This randomized clinical trial evaluated the effectiveness of 38% SDF, 5% sodium fluoride (NaF) varnish and placebo control in preventing approximal caries in primary teeth.

Children aged 4-6 years who had at least one sound approximal surface at the distal surface of canines or the mesial or distal surface of the first and second molars assessed from bitewing radiographs were recruited. The participants were randomly allocated into three intervention groups as follows: Group 1 = control (water) , Group 2 = 5% NaF varnish (Duraphat) and Group 3 = 38% SDF (Topamine). All agents were applied semi-annually and the new caries development was assessed by the bitewing radiographic examinations at 6-, 12-, and 18-month follow-ups by two blind calibrated investigators.

The new approximal caries development rates of Group 1, 2, and 3 at the 18-month examination were 22.5%, 13.6%, and 24.3%, respectively (p<0.001). Based on these results, the semi-annual application of 5% NaF varnish is more effective than that of 38% SDF and the placebo control in preventing approximal caries in primary teeth.

View this poster presentation in the IADR General Session Virtual Experience Platform.

Wednesday, July 14, 2021

Study reveals new aspects of gingivitis and body's response


Links to other health issues suggested

UNIVERSITY OF WASHINGTON SCHOOL OF DENTISTRY

Research News

IMAGE

IMAGE: A GINGIVAL BACTERIAL SAMPLE IS TAKEN FROM A SUBJECT. view more 

CREDIT: DR. SHATHA BAMASHMOUS, UNIVERSITY OF WASHINGTON SCHOOL OF DENTISTRY

UW researchers reveal new aspects of gum disease and body's protective response

SEATTLE - A team led by University of Washington researchers has, for the first time, identified and classified how different people respond to the accumulation of dental plaque, the sticky biofilm that gathers on teeth. Their work, recently published in the journal Proceedings of the National Academy of Sciences of the United States of America (PNAS), sheds important new light on why some people may be more prone to serious conditions that lead to tooth loss and other problems.

Left unchecked, plaque buildup can induce gingivitis, or gum inflammation. Gingivitis, in turn, can lead to periodontitis, a serious gum infection that damages the soft tissue and can destroy the bone that supports teeth. Not only can this result in tooth loss, but chronic inflammation can also spur other serious health consequences, including heart disease, diabetes, cancer, arthritis, and bowel diseases.

The researchers also found a previously unidentified range of inflammatory responses to bacterial accumulation in the mouth. When bacteria build up on tooth surfaces, it generates inflammation, a tool the body uses to tamp down the buildup. Previously, there were two known major oral inflammation phenotypes, or individual traits: a high or strong clinical response and a low clinical response. The team identified a third phenotype, which they called "slow": a delayed strong inflammatory response in the wake of the bacterial buildup.

The study revealed for the first time that subjects with low clinical response also demonstrated a low inflammatory response for a wide variety of inflammation signals. "Indeed, this study has revealed a heterogeneity in the inflammatory response to bacterial accumulation that has not been described previously," said Dr. Richard Darveau of the UW School of Dentistry, one of the study's authors.

His School of Dentistry colleague and study co-author Dr. Jeffrey McLean said, "We found a particular group of people that have a slower development of plaque as well as a distinct microbial community makeup prior to the start of the study." The study authors wrote that understanding the variations in gum inflammation could help better identify people at elevated risk of periodontitis. In addition, it is possible that this variation in the inflammatory response among the human population may be related to susceptibility to other chronic bacterial-associated inflammatory conditions such as inflammatory bowel disease.

In addition, the researchers found a novel protective response by the body, triggered by plaque accumulation, that can save tissue and bone during inflammation. This mechanism, which was apparent among all three phenotypes, utilizes white blood cells known as neutrophils. In the mouth, they act something like cops on the beat, patrolling and regulating the bacterial population to maintain a stable condition known as healthy homeostasis.

In this instance, plaque is not a villain. To the contrary, the researchers said that the proper amount and makeup of plaque supports normal tissue function. Studies in mice have also shown that plaque also provides a pathway for neutrophils to migrate from the bloodstream through the gum tissue and into the crevice between the teeth and gums.

When healthy homeostasis exists and everything is working right, the neutrophils promote colonization resistance, a low-level protective inflammatory response that helps the mouth fend off an excess of unhealthy bacteria and resist infection. At the same time, the neutrophils help ensure the proper microbial composition for normal periodontal bone and tissue function.

The researchers' findings underscore why dentists preach the virtues of regular brushing and flossing, which prevent too much plaque buildup. "The idea of oral hygiene is to in fact recolonize the tooth surface with appropriate bacteria that participate with the host inflammatory response to keep unwanted bacteria out," Dr. Darveau said. The bacteria start repopulating the mouth's surfaces spontaneously and almost immediately afterward, he said.

Friday, July 9, 2021

Tooth loss associated with increased cognitive impairment, dementia


Good oral health, including dentures, may protect against cognitive decline

NEW YORK UNIVERSITY

Research News

Tooth loss is a risk factor for cognitive impairment and dementia--and with each tooth lost, the risk of cognitive decline grows, according to a new analysis led by researchers at NYU Rory Meyers College of Nursing and published in JAMDA: The Journal of Post-Acute and Long-Term Care Medicine. However, this risk was not significant among older adults with dentures, suggesting that timely treatment with dentures may protect against cognitive decline.

About one in six adults aged 65 or older have lost all of their teeth, according to the Centers for Disease Control and Prevention. Prior studies show a connection between tooth loss and diminished cognitive function, with researchers offering a range of possible explanations for this link. For one, missing teeth can lead to difficulty chewing, which may contribute to nutritional deficiencies or promote changes in the brain. A growing body of research also points to a connection between gum disease--a leading cause of tooth loss--and cognitive decline. In addition, tooth loss may reflect life-long socioeconomic disadvantages that are also risk factors for cognitive decline.

"Given the staggering number of people diagnosed with Alzheimer's disease and dementia each year, and the opportunity to improve oral health across the lifespan, it's important to gain a deeper understanding of the connection between poor oral health and cognitive decline," said Bei Wu, PhD, Dean's Professor in Global Health at NYU Rory Meyers College of Nursing and co-director of the NYU Aging Incubator, as well as the study's senior author.

Wu and her colleagues conducted a meta-analysis using longitudinal studies of tooth loss and cognitive impairment. The 14 studies included in their analysis involved a total of 34,074 adults and 4,689 cases of people with diminished cognitive function.

The researchers found that adults with more tooth loss had a 1.48 times higher risk of developing cognitive impairment and 1.28 times higher risk of being diagnosed with dementia, even after controlling for other factors.

However, adults missing teeth were more likely to have cognitive impairment if they did not have dentures (23.8 percent) compared to those with dentures (16.9 percent); a further analysis revealed that the association between tooth loss and cognitive impairment was not significant when participants had dentures.

The researchers also conducted an analysis using a subset of eight studies to determine if there was a "dose-response" association between tooth loss and cognitive impairment--in other words, if a greater number of missing teeth was linked to a higher risk for cognitive decline. Their findings confirmed this relationship: each additional missing tooth was associated with a 1.4 percent increased risk of cognitive impairment and 1.1 percent increased risk of being diagnosed with dementia.

"This 'dose-response' relationship between the number of missing teeth and risk of diminished cognitive function substantially strengthens the evidence linking tooth loss to cognitive impairment, and provides some evidence that tooth loss may predict cognitive decline," said Xiang Qi, a doctoral candidate from NYU Meyers.

"Our findings underscore the importance of maintaining good oral health and its role in helping to preserve cognitive function," said Wu.